Research projects
Please support any of these projects with a $1.00 or 1 euro donation to the PayPal account:
Effects of praying the rosary on wellbeing
The goal of this project is to investigate the effects of praying the rosary for 6 months on anxiety, lipid panel, blood glucose,, blood pressure and liver functions.
Effects of Eucharistic Adoration on wellbeing
The goal of this project is to investigate the effects daily Eucharistic Adoration during 6 months on anxiety, lipid panel, blood glucose, blood pressure and liver functions.
St. Hildegard's medicine scientific validation
To determine the impact of St. Hildegard's lavender beverage on liver functions in patients with fatty liver disease.
My scientific publications:
Peer review articles
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Loarca L, Sassi-Gaha S, Artlett CM. α-dicarbonyls downregulate migration, invasion, and adhesion of liver cancer cells in a p53-dependent manner. Dig Liver Dis. 2013 Nov;45(11):938-46. Karjoo S, Hand NJ, Loarca L, Russo PA, Friedman JR, Wells RG. Extrahepatic cholangiocyte cilia are abnormal in biliary atresia. J Pediatr Gastroenterol Nutr. 2013 Jul;57(1):96-101.
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O'Hara SP*, Splinter PL*, Trussoni CE, Pisarello MJ, Loarca L, Splinter NS, Schutte BF, LaRusso NF. ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A. J Biol Chem. 2017 Mar 24;292(12):4833-4846. (*equally contributed)
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Loarca L*, De Assuncao TM*, Jalan-Sakrikar N, Bronk S, Krishnan A, Huang B, Morton L, Trussoni C, Bonilla LM, Krueger E, O'Hara S, Splinter P, Shi G, Pisarello MJL, Gores GJ, Huebert RC, LaRusso NF. Development and Characterization of Cholangioids from Normal and Diseased Human Cholangiocytes as an In Vitro Model to Study Primary Sclerosing Cholangitis. Lab Invest. 2017 Nov;97(11):1385-1396. (*first authors, selected as cover page)
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Masyuk Al, Masyuk TV, Lorenzo Pisarello MJ, Ding JF, Loarca L, Huang BQ, LaRusso NF. Cholangiocyte Autophagy Contributes to Hepatic Cystogenesis in Polycystic Liver Disease and Represents a Potential Therapeutic Target. Hepatology. 2017 Oct;10. doi: 10.1002/hep.29577
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Choi JH, Loarca L, De Hoyos-Vega JM, Dadgar N, Loutherback K, Shah VH, Stybayeva G, Revzin A. Microfluidic confinement enhances phenotype and function of hepatocyte spheroids. Physiol Cell Physiol. 2020 Sep;319(3):C552-C560.
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Bouzhir L*, Gontran E*, Loarca L, Collado-Hilly M, Dupuis-Williams P. Generation and Quantitative Characterization of Functional and Polarized Biliary Epithelial Cysts. J Vis Exp. 2020 May;16 (159). doi: 10.3791/61404. (*first authors)
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Jalan-Sakrikar N, De Assuncao TM, Hamdan FH, Navarro-Corcuera, A, Loarca L, Kirkeby L, Resch ZT, Rosen CB, Heimbach JK, Taner T, Steven J, Shah VH, LaRusso NF, Huebert RC. Cholangiocytes in Primary Sclerosing Cholangitis are Intrinsically Predisposed to Cellular Senescence. Hepat Commun. 2022 6(2):345-360.
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Gontran E*, Loarca L*#, El Kassis C, Bouzhir L, Ayollo D, Mazari-Arrighi E, A Fuchs, Dupuis-Williams P#. Self-organogenesis from 2D micropatterns to 3D biomimetic biliary trees. Bioengineering (Basel). 2021 8(8):112. (*co-first authors, #co-corresponding authors, selected as cover page)
Reviews and book chapters
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Loarca L*, Fraietta JA*, Pirrone V, Szep Z and Wigdahl B (2017). Human Immunodeficiency Virus (HIV) Infection and Cancer, HIV/AIDS -Contemporary Challenges, Dr. Nancy Dumais (Ed.), InTech, doi: 10.5772/67162. (*equally contributed)
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Loarca L, Sullivan N, Pirrone V, Wigdahl, B (2015). Leukemias -Updates and New Insides. Leukemia and Retroviral Disease. Intech. 2015 doi: 10.5772/61254
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Pisarello MJ, Loarca L, Ivanics T, Morton L, LaRusso N. MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis, and Treatment. J Clin Med. 2015 Aug;4(9):1688-712.
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Loarca L, Pisarello MJ, Morton L, Huang, BQ, O’Hara SP, Splinter P, LaRusso NF (2016). Primary Sclerosing Cholangitis, Cholangiogyte Biology, Dr. Lisa M Forman (Ed.), Springer.